Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
USERS' SCORE
Good
Based on 21 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Quercetin
500 mg
†
Top Medical Research Studies
8
We explored the effects of quercetin on cardiac fibrosis, a major concern in cardiovascular diseases. Using an experiment on mice, we administered quercetin after inducing cardiac stress and assessed its impact on heart function and fibrosis. Our findings showed that quercetin significantly reduced cardiac fibrosis and helped reverse cell proliferation caused by stress hormones. This protective effect was linked to its regulation of the SIRT3 signaling pathway. Overall, quercetin presents a promising avenue for addressing heart fibrosis.
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8
We examined the effects of quercetin on heart damage following a heart attack in rats. In our study, quercetin was administered just before reperfusion after a blockage in the heart's blood supply.
The results showed that quercetin significantly improved heart function and reduced harmful neutrophil formations. By lowering these formations, we believe quercetin may offer new hope as a protective treatment against heart injuries caused by reperfusion and inflammation.
The results showed that quercetin significantly improved heart function and reduced harmful neutrophil formations. By lowering these formations, we believe quercetin may offer new hope as a protective treatment against heart injuries caused by reperfusion and inflammation.
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9.5
Quercetin improves post-MI recovery
We investigated the potential of quercetin, a natural compound found in fruits and vegetables, to prevent challenges after a heart attack (myocardial infarction, or MI). By treating mice with quercetin before inducing MI, we observed significant improvements in heart function, survival rates, and reduced heart damage caused by inflammation and fibrosis.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
Read More
Most Useful Reviews
9
Reduces allergy symptoms
2 people found this helpful
An excellent antioxidant, quercetin strengthens capillaries and supports cardiovascular health. I buy it for my mother to alleviate allergy symptoms, as it blocks histamine production effectively.
Read More
9
Broad health benefits
Quercetin is vital today, offering benefits for cardiovascular health, immunity, and reducing inflammation. It’s more convenient than consuming large amounts of vegetables.
Read More
9
Supports cardiovascular health
12 people found this helpful
Quercetin is an exceptionally powerful antioxidant that fortifies cell membranes against free radicals, making it beneficial in preventing cardiovascular disease. Its antiallergic properties help manage conditions like arthritis and asthma. I followed a natural pathologist's advice to take 1000 mg twice a day to alleviate a rash; it seems to work.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 14 Researches
8.3
- All Researches
9.5
Quercetin improves post-MI recovery
We investigated the potential of quercetin, a natural compound found in fruits and vegetables, to prevent challenges after a heart attack (myocardial infarction, or MI). By treating mice with quercetin before inducing MI, we observed significant improvements in heart function, survival rates, and reduced heart damage caused by inflammation and fibrosis.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
Read More
9
We examined the impact of Danggui Buxue Decoction (DBD), a traditional Chinese remedy, on atherosclerotic plaques in a mice model. Using a blend of advanced bioinformatics and experimental validation, we discovered that DBD can effectively stabilize these plaques.
Key ingredients like quercetin played a significant role in this process by targeting several important proteins that influence inflammation and lipid metabolism. Our findings suggest that quercetin and another compound, kaempferol, work together to improve heart health by reducing atherosclerotic vulnerability.
Key ingredients like quercetin played a significant role in this process by targeting several important proteins that influence inflammation and lipid metabolism. Our findings suggest that quercetin and another compound, kaempferol, work together to improve heart health by reducing atherosclerotic vulnerability.
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9
We examined how quercetin might protect against heart issues associated with menopause, particularly by looking at its effects on cardiac reperfusion arrhythmias in ovariectomized rats. Over a four-week period, we found that quercetin significantly reduced heart damage and improved mitochondrial function by enhancing ATP production. This suggests quercetin may help manage some heart health risks tied to decreased estrogen levels. While our findings are promising, further research in humans is needed to confirm these effects.
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9
We investigated the effects of quercetin (QUE), a natural dietary phytochemical, on platelet toxicity induced by extracellular histones, which can harm our body during critical illnesses.
In our study, we set up experiments to observe how histones trigger platelet activation and the protective influence of QUE. Our findings revealed that QUE successfully reduced platelet activation and protected against stress-induced damage.
This suggests that quercetin could be a promising candidate for addressing platelet-related issues associated with histones.
In our study, we set up experiments to observe how histones trigger platelet activation and the protective influence of QUE. Our findings revealed that QUE successfully reduced platelet activation and protected against stress-induced damage.
This suggests that quercetin could be a promising candidate for addressing platelet-related issues associated with histones.
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9
We developed an innovative biosensing platform to explore how quercetin affects heart cells, especially during cardiac oxidative stress. By testing cardiomyocytes, we found that quercetin can protect against injury caused by oxidative stress, highlighting its potential as a therapeutic option.
However, we also determined a safe concentration limit and noted potential long-term effects on heart cells. This balanced evaluation not only sheds light on quercetin's advantages but also emphasizes the need for careful consideration in its use for cardiovascular health.
However, we also determined a safe concentration limit and noted potential long-term effects on heart cells. This balanced evaluation not only sheds light on quercetin's advantages but also emphasizes the need for careful consideration in its use for cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 21 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces allergy symptoms
2 people found this helpful
An excellent antioxidant, quercetin strengthens capillaries and supports cardiovascular health. I buy it for my mother to alleviate allergy symptoms, as it blocks histamine production effectively.
Read More
9
Broad health benefits
Quercetin is vital today, offering benefits for cardiovascular health, immunity, and reducing inflammation. It’s more convenient than consuming large amounts of vegetables.
Read More
9
Supports cardiovascular health
12 people found this helpful
Quercetin is an exceptionally powerful antioxidant that fortifies cell membranes against free radicals, making it beneficial in preventing cardiovascular disease. Its antiallergic properties help manage conditions like arthritis and asthma. I followed a natural pathologist's advice to take 1000 mg twice a day to alleviate a rash; it seems to work.
Read More
9
Anti-inflammatory benefits
9 people found this helpful
I highly recommend quercetin for its anti-inflammatory properties. It aids in preventing and treating conditions like arthritis and cardiovascular disease. Additionally, it alleviates pain and has antihistamine effects, making it a suitable alternative to traditional allergy medications. Quercetin also positively impacts my overall health.
Read More
7.5
Improved health metrics
3 people found this helpful
Quercetin is a widely available flavonoid in fruits and vegetables, and I've been consuming it for over a year. My recent health checks showed reductions in LDL cholesterol and blood pressure, underscoring its role in preventing cardiovascular disease.
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Frequently Asked Questions
7.5
Improved health metrics
3 people found this helpful
Quercetin is a widely available flavonoid in fruits and vegetables, and I've been consuming it for over a year. My recent health checks showed reductions in LDL cholesterol and blood pressure, underscoring its role in preventing cardiovascular disease.
7.5
Supports heart health
Effective; I have heard this is beneficial for cardiovascular disease and plan to take it for an extended period.
9
Reduces allergy symptoms
2 people found this helpful
An excellent antioxidant, quercetin strengthens capillaries and supports cardiovascular health. I buy it for my mother to alleviate allergy symptoms, as it blocks histamine production effectively.
9
Supports cardiovascular health
12 people found this helpful
Quercetin is an exceptionally powerful antioxidant that fortifies cell membranes against free radicals, making it beneficial in preventing cardiovascular disease. Its antiallergic properties help manage conditions like arthritis and asthma. I followed a natural pathologist's advice to take 1000 mg twice a day to alleviate a rash; it seems to work.
7.5
Soothes allergies
1 people found this helpful
It soothes nasal congestion and skin allergies while benefiting cardiovascular health. Combining it with green tea enhances its immune-supportive effects.
7.5
Active antioxidant
Quercetin, a flavonol and effective antioxidant, supports cardiovascular disease by reducing LDL oxidation and is highly active as an antioxidant.
9
Anti-inflammatory benefits
9 people found this helpful
I highly recommend quercetin for its anti-inflammatory properties. It aids in preventing and treating conditions like arthritis and cardiovascular disease. Additionally, it alleviates pain and has antihistamine effects, making it a suitable alternative to traditional allergy medications. Quercetin also positively impacts my overall health.
7.5
Protects against disease
13 people found this helpful
Excellent! Quercetin effectively protects against free radicals, aiding in the prevention of cardiovascular disease. It combats inflammation, allergies, and pain syndromes. While the usual dose is 500 mg twice daily, smaller doses may also be beneficial. However, common side effects include headaches and stomach upset, and excessive amounts could harm the kidneys.
7.5
Helps manage condition
8 people found this helpful
Taking 1000 mg of quercetin twice daily has significantly helped me manage Mast Cell Disease. I find that various brands from iHerb are effective, but I appreciate this bulk packaging more. Its benefits extend even to cardiovascular disease.
9.5
Quercetin improves post-MI recovery
We investigated the potential of quercetin, a natural compound found in fruits and vegetables, to prevent challenges after a heart attack (myocardial infarction, or MI). By treating mice with quercetin before inducing MI, we observed significant improvements in heart function, survival rates, and reduced heart damage caused by inflammation and fibrosis.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
The study also revealed that quercetin helps shift immune cells toward a healing state, crucial for recovery. This promising research opens the door for quercetin's use in treating cardiac issues related to heart attacks.
8
Quercetin and curcumin synergize cardiovascular effects
We investigated how quercetin, specially prepared in solid lipid nanoparticles, works alongside curcumin to combat atherosclerosis. Using human vascular smooth muscle cells, we treated them with these compounds and observed their effects on inflammation and oxidative stress.
Our results showed that this combination significantly reduced harmful oxidative stress and inflammation associated with a key signaling pathway in cells. This suggests that their synergistic effect could offer a promising new treatment for cardiovascular diseases linked to chronic inflammation.
Our results showed that this combination significantly reduced harmful oxidative stress and inflammation associated with a key signaling pathway in cells. This suggests that their synergistic effect could offer a promising new treatment for cardiovascular diseases linked to chronic inflammation.
8
We explored the effects of quercetin on cardiac fibrosis, a major concern in cardiovascular diseases. Using an experiment on mice, we administered quercetin after inducing cardiac stress and assessed its impact on heart function and fibrosis. Our findings showed that quercetin significantly reduced cardiac fibrosis and helped reverse cell proliferation caused by stress hormones. This protective effect was linked to its regulation of the SIRT3 signaling pathway. Overall, quercetin presents a promising avenue for addressing heart fibrosis.
8
We investigated how quercetin affects blood pressure in female rats with induced hypertension. After administering quercetin, we observed a drop in their blood pressure and improvements in the condition of their aortic vessels. This suggests that quercetin can help manage blood pressure effectively in this setting. However, while we noted some changes in how blood vessels reacted to stimuli, more research is needed to fully understand quercetin's impact on renal arteries and its potential as a treatment for hypertension.
References
- Ji K, Han M, Yang M, Xu Q, Zhang Y. Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy. Front Cardiovasc Med. 2025;12:1454647. 10.3389/fcvm.2025.1454647
- Shamsi M, Mohammadzadeh G, Hatami M, Roshanazadeh M, Noor-Behbahani M, et al. Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin Loaded in Solid Lipid Nanoparticles and Curcumin in Atherosclerosis Therapy. Iran J Pharm Res. 2024;23:e151428. 10.5812/ijpr-151428
- Wang L, Lin S, Wei Q, Li T, Mo Q, et al. Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization. Int Immunopharmacol. 2025;151:114296. 10.1016/j.intimp.2025.114296
- Zheng G, Cao X, Jing Y, Wang L, Yan R, et al. An integrative approach for mechanistic insights into the atherosclerotic plaque-stabilizing properties of Danggui Buxue decoction. J Ethnopharmacol. 2025;343:119450. 10.1016/j.jep.2025.119450
- Domingos AE, Breves CMDC, Boa LF, de Souza IIA, Maciel L, et al. Quercetin Reduces the Susceptibility to Cardiac Reperfusion Arrhythmias in Ovariectomized Rats. Mol Nutr Food Res. 2025;69:e202400284. 10.1002/mnfr.202400284
- Manikanta K, NaveenKumar SK, Hemshekhar M, Thushara RM, Mugesh G, et al. Quercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone. Phytomedicine. 2025;138:156386. 10.1016/j.phymed.2025.156386
- Long X, Tao S, Yang S, Li S, Rao L, et al. Quercetin improves heart failure by inhibiting cardiomyocyte apoptosis suppressing the MAPK signaling pathway. Nan Fang Yi Ke Da Xue Xue Bao. 2025;45:187. 10.12122/j.issn.1673-4254.2025.01.22
- Kasahara K, Kerby RL, Aquino-Martinez R, Evered AH, Cross TL, et al. Gut microbes modulate the effects of the flavonoid quercetin on atherosclerosis. NPJ Biofilms Microbiomes. 2025;11:12. 10.1038/s41522-024-00626-1
- Mahyar M, Ghadirzadeh E, Nezhadnaderi P, Moayedi Z, Maboud P, et al. Neuroprotective effects of quercetin on hippocampal CA1 neurons following middle cerebral artery ischemia‒reperfusion in male rats: a behavioral, biochemical, and histological study. BMC Neurol. 2025;25:9. 10.1186/s12883-024-04017-z
- Mkhize SA, Nthlane RA, Xhakaza SP, Verhaert PD, Baijnath S, et al. Decreased blood pressure with acute administration of quercetin in L-NAME-induced hypertensive rats. Basic Clin Pharmacol Toxicol. 2025;136:e14113. 10.1111/bcpt.14113
- Lin DW, Jiang YW, Wu C, Zhang H, Li YZ, et al. Quercetin Alleviates Cardiac Fibrosis via Regulating the SIRT3 Signaling Pathway. Cardiovasc Drugs Ther. 2024. 10.1007/s10557-024-07658-x
- Chen J, Lyu X, Yuan Q, Qin C, Yu H, et al. Dynamic and quantitative assessment of quercetin for cardiac oxidative stress injury prevention using sensitive cardiomyocyte based biosensing. Biosens Bioelectron. 2025;271:117045. 10.1016/j.bios.2024.117045
- Scalise M, Cianflone E, Quercia C, Pagano L, Chiefalo A, et al. Senolytics rejuvenate aging cardiomyopathy in human cardiac organoids. Mech Ageing Dev. 2025;223:112007. 10.1016/j.mad.2024.112007
- Goshovska Y, Pashevin D, Goncharov S, Lapikova-Bryhinska T, Lisovyi O, et al. Quercetin is a potential therapy for post-infarction NETosis formation. Naunyn Schmiedebergs Arch Pharmacol. 2025;398:5705. 10.1007/s00210-024-03602-w
